May 14 (Reuters) – AstraZeneca said on Thursday that a late-stage trial of Imfinzi, combined with a targeted therapy prior to a surgery, showed significantly improved survival rate in patients with muscle-invasive bladder cancer.
The Anglo-Swedish drugmaker, however, said overall survival from a combination of its two cancer drugs Imfinzi and Imjudo with the pre-surgery drug was not statistically significant in the trial.
Here are some details:
• Imfinzi given before and after surgery, together with pre-procedure enfortumab vedotin (EV), delivered statistically significant improvements in both event-free survival and overall survival, AstraZeneca said.
• Enfortumab vedotin is a drug given to patients prior to the surgery to shrink the tumour.
• The safety and tolerability of Imfinzi with or without the other drugs was consistent with the known safety profiles of the individual medicines, and there were no new safety signals.
• About one in four patients with bladder cancer has muscle-invasive disease, where the tumour invades the muscle wall of the bladder, without distant metastases, the company said.
(Reporting by Shashwat Awasthi in Bengaluru; Editing by Sherry Jacob-Phillips)
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